| # | Children | Name | Born | Died | Father | Mother |
| 1 | Yes | | b. 14 Dec 1748 | d. 28 Jul 1811 | His Grace William CAVENDISH, 4th Duke of Devonshire, KG, PC | Rt. Hon. Lady Charlotte Elizabeth BOYLE, Marchioness of Hartington, 6th Baroness Clifford |
| 2 | | | b. 27 Aug 1750 | d. 3 Jun 1794 | His Grace William CAVENDISH, 4th Duke of Devonshire, KG, PC | Rt. Hon. Lady Charlotte Elizabeth BOYLE, Marchioness of Hartington, 6th Baroness Clifford |
| 3 | | | b. 9 Jun 1752 | d. 7 Sep 1781 | His Grace William CAVENDISH, 4th Duke of Devonshire, KG, PC | Rt. Hon. Lady Charlotte Elizabeth BOYLE, Marchioness of Hartington, 6th Baroness Clifford |
| 4 | Yes | | b. 31 Mar 1754 | d. 9 May 1834 | His Grace William CAVENDISH, 4th Duke of Devonshire, KG, PC | Rt. Hon. Lady Charlotte Elizabeth BOYLE, Marchioness of Hartington, 6th Baroness Clifford |